Meeting the Needs of a Potent Carrier for Malaria Treatment: Encapsulation of Artemisone in Poly(lactide‐ <i>co</i> ‐glycolide) Micro‐ and Nanoparticles

Biodegradable polymer nano- and microparticles are of interest as drug carriers due to their capability modulate release. Two different methods, including solvent displacement spray drying, used, resulting in the fabrication Artemisone (ART)-loaded polymeric microparticles, respectively. Scanning electron microscopy, transmission dynamic light scattering, asymmetric flow field fractionation (AF4) employed evaluate morphology size particles. The encapsulation loading efficiency well cumulative release characterized using high-performance liquid chromatography (HPLC). HPLC results confirm that drying method provides higher efficiencies about 97%, whereas, nanoparticles prepared by displacement, highest is 71%. Using these production round-shaped particles with homogeneous distribution fabricated. Moreover, preparation procedure optimized obtain efficiency. method, stable dispersions water obtained without adding any surfactant, for spray-dried tween 80 needed redisperse micro- show properties, which delivery application hydrophobic drugs like ART.